What would you say you do here? Understanding our genes, with big help from small RNAs

What would you say you do here? Understanding our genes, with big help from small RNAs

July 22 The Broad Institute of MIT and Harvard

Wednesday, July 22, 2015 - 6:00pm

Wednesday, July 22, 6-7pm

What would you say you do here? Understanding our genes, with big help from small RNAs.
While we've had the parts list of the human genome (the 3 billion As, Cs, Gs, and Ts that make up our genetic code) for over a decade, the functions of most genes remains obscure. Yet knowing what genes do is critical for understanding how their dysfunction leads to disease and thus how to develop therapeutic interventions. In this talk, Doench, a senior group leader in the Broad’s Genetic Perturbation Platform, will describe how scientists “break” genes in order to discern their function, using tools re-purposed from the ancient and ongoing evolutionary struggle between organisms and deviant nucleic acids such as viruses. He will also show how the application of these tools can provide insight into biological problems, with an example from recent work focused on malaria.

Speaker: John Doench
John G. Doench is a senior group leader in the Genetic Perturbation Platform at the Broad Institute. He develops and applies the latest approaches in functional genomics -- including RNAi, ORF, and CRISPR technologies -- to understand the function of genes and how gene dysfunction leads to disease. Doench collaborates with researchers across the Broad, the Boston community, and the world to develop faithful biological models and execute genetic screens.

Prior to joining the Broad in 2009, Doench did his postdoctoral work at Harvard Medical School and received his Ph.D. from the biology department at MIT. A history major at Hamilton College, John deeply values the broad-minded thinking and focus on written and oral presentation skills that are critical to a liberal arts education.

John lives in Jamaica Plain with his wife and daughter, where he enjoys coaching soccer, cheering on the Red Sox and Patriots, and avoiding imminent death while navigating the streets of Boston on a bicycle.

Register here: https://msns15-johndoench.eventbrite.com

Science & Technology
Lectures
$0.00
Phone Number: 
617-714-7000